The Vinewood sign from Grand Theft Auto: San Andreas is clearly visible in one section, suggesting that at least some of the gaming environment and the environment will appear again. The private jet burning through the end, suggests that we will be able to fly the aircraft again.
As with Grand Theft Auto IV, it seems that developer Rockstar North is looking to add social comments to the set. Some moments show the firing homeless under a bridge and beg for change. The contrast between rich and poor seems to be a key issue.